Comparatively, probiotic use is much safer than antibiotic use. 

Instead of eliminating both helpful and harmful bacteria like antibiotics, probiotics introduced in the right quantities can turn the tables, restraining the development of harmful bacterias while boosting good bacteria. 

Probiotics like Bacillus clausii, Bacillus subtilis, Bacillus coagulans, Bifidobacteria, Lactobacillus, etc. are recognized and continuously studied for their safety and remarkable effectiveness.

Currently, there are some technical barriers when producing microbial products containing probiotics. These barriers and challenges affect the ultimate effectiveness, sustainability, and durability of finished products: 

  • Probiotics that are alive, activated, or exhibit metabolic activities, tend to not survive the storage and transportation stages of the finished product. 

  • This is why traditionally, "live probiotics" products cannot be stored for long and become ineffective as soon as they leave the factory for transportation.

In the sector of probiotic supplements for gut health, most products contain probiotic strains like Lactobacillus and Bifidobacteria which cannot form "spore" status and are not able to survive through transportation, storage, extreme temperatures or stomach acid. Rendering them hugely ineffective and mostly "dead" even before reaching the intestinal microflora. 

Lactobacillus

Bifidobacteria

Spore probiotics

Only in the "spore" status where bacteria are enclosed and protected by a durable shell cover can probiotics overcome the technical barriers listed above. 

Live spore probiotics have time durability, transportation, and storage durability, as well as heat and acid resilience.

TURNING PROBIOTICS INTO SPORE FORM IS NOT DIFFICULT, THE CHALLENGE LIES IN MAINTAINING SUSTAINABILITY OF PROBIOTICS' SPORE STATUS THROUGH FLUCTUATIONS OF THE EXTERNAL ENVIRONMENT 

 

The Live Spore Probiotics SPL Technology innovation of Dr. Nguyen Hoa Anh and his colleagues at the National Key Library of Enzyme and Protein Technology holds great scientific significance for microbial biotechnology. The SPL innovation and methodology has been proven and recognized for its capacity to not only resolve traditional technical barriers of live probiotics production but also opening new doors for the future of microbial biotechnology and humankind.

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Technology breakthroughs

The Dangers of Antibiotic Use and Antibiotic-Resistance

Antibiotics support the body by stopping infections and attacks caused by harmful bacterias. Unfortunately, antibiotics also end up killing helpful bacteria like probiotics, causing imbalance in the microbiome, releasing toxins that affect the health of many other organs, and side-effects like inflammation, allergies, and digestive disorders. Side-effects of antibiotics could lead to the development of more serious diseases but more importantly, pose risks of generating widespread super-bacteria that are drug-resistant, vaccine-resistant, and antibiotic-resistant.

Probiotics: The Solution & The Future

HEAT RESISTANT

AND TIME DURABILITY

Helpful bacteria like Bacillus clausii, Bacillus subtilis, and Bacillus coagulans can maintain long term spore status, having limitless durability to sustain lengthy transportation and storage even at extremely cold or high temperatures up to 60-70*C.

ACID DURABILITY

Nearly all probiotic spores will be acid-resistant and able to bypass even stomach acid to reach the intestinal microflora and fully germinate.

THE BEST TRANSMITTED

DOSAGE FORM

For optimum effectiveness, probiotics should come in mixtura form. In reality, this is difficult and poses high risks of spores re-germinating into bacteria form during storage or transportation. Dr. Anh's SPL innovation overcomes this limitation as well, ensuring probiotics stay in spore form and do not germinate until they reach their destination.

*Though the first probiotics spore mixtura was invented in 1959, there have been few big pharmaceutical firms in the world capable of successfully producing sustainable probiotics spore mixtura on a larger and consistent scale.

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    Bacillus clausii

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    Bacillus subtilis

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    Bacillus coagulans

Multi-Stage Quality Control Policies

1. Quality Control of Raw Materials


As a market-leading manufacturer in the field of microbial technology, the safety of our products is one of our first concerns. Our raw materials arrive, carefully sourced from certified and safe entities, and then assessed according to strict quality control requirements before quality production lines.




2. Quality Control of Production Processes


- Our production and manufacturing processes meet GMP and ISO standards evaluated and appraised through third party control by independent and reputable organizations - Our probiotics are manufactured according to ISO 22000:2005 standards in food safety management systems in the sector of probiotics production. (Certified by VINCERT) - Our probiotics also adhere to controls necessitated by the TCVN 5603:2008 certificate on hazard analysis and critical control systems in the sector of probiotics production. (Certified by VINCERT)




3. Quality Control of Finished Product


- Before being distributed to the market, all our products are randomized, simultaneously and independently checked by our laboratory as well as by The Key Laboratory of Enzyme and Protein Technology (KLEPT) at The University of Sciences under The Vietnam National University, Hanoi. - Factory products are required to meet standards for global export such as guaranteeing The United States Pharmacopeia <61>.





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OUR STORY

Spohalo Probiotics PTE. LTD.

Address: 68 Circular Road #02-01, Singapore (049422)
Tel: 1 (888) 588-2518
Email: hello@livespo-probiotics.com

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